The transient dynamics analysis of the new driving drum is carried out by using ANSYS,its maximum equivalent stress cloud pictures and maximum principal stress time history in different work conditions are obtained. The rain-flow counting,the load extrapolation and superposition of the maximum equivalent stress time history of the dangerous area of the driving drum are carried out by using Rainflow module in n Code Glyph Works. Based on the relative theory of fatigue life prediction,stress life module is used to analyze the fatigue life and fatigue sensitivity of the driving drum. The damage histogram of the driving drum and the minimum fatigue life curves of the driving drum under the different inputted parameters are obtained. The results show that the driving drum has a good mechanical property,the minimum fatigue life of the driving drum is about 783 days to meet use requirements. The overload and residual stress have obvious influence on the fatigue life of the driving drum.